The park is home to significant spiritual centers like the Sanctuary of La Verna, where St. Francis of Assisi received the stigmata, and the Camaldoli Monastery and Hermitage. The region's history is visible in its medieval castles and fortresses; the imposing Poppi Castle, residence of the Guidi Counts, stands as a prime example of an aristocratic palace and pre-Renaissance military architecture, while the ruins of Romena Castle offer panoramic views. Events in the park celebrate nature and tradition, including autumnal mushroom and chestnut festivals, guided wildlife watching tours, and cultural events in historic villages like Stia and Bagno di Romagna. Nearby attractions include the historic cities of Florence and Arezzo, the thermal spas of Bagno di Romagna, and the source of the Arno River on Monte Falterona, all connected by an extensive network of trails.